Research
Cell Biology
Developmental Biology
Genetics
Genomics
Molecular Biology
- Roles of the tumor suppressor BRCA2 in DNA repair and cell cycle control.
- Regulation of mitosis and the development of chromosome instability in cancer (CIN)
- Telomere maintenance and cancer susceptibility
- Development and analyses of mouse and zebrafish models for CIN type cancer.
Education/Career/Awards
Education
2000.08-2002.09
Wellcome Trust Postdoctoral Fellowship (Wellcome Trust Prize Award); Prof. David Kimelman; Univ. of Washington, Seattle. Dept. of Biochemistry
2000.01-2000.08
- Wellcome Trust Postdoctoral Fellowship (Wellcome Trust Prize Award); Prof. Frank McKeon; Harvard Medical School, Dept. of Cell Biology
1996.10-1999.11
- Ph.D. : Cambridge University (MRC, Lab of Molecular Biology), UK
1990.03-1992.02
- Master : Seoul National University
1986.03-1990.02
- Bachelor : Ewha womans University
Career
2021.02-present
Head of Research, Seoul National University
2021.02-present
Member, Institution of Gifted Education, Ministry of Education, Republic of Korea
2021.02-present
External Advisor, Science & Technology Policy Institute
2020.08–2021.02
Visiting Researcher, Samsung Advanced Institute of Technology (SAIT)
2020.08–2023
Director, Suh Kyeongbae Foundation (SURF)
2019.10–2021.01
Member, Seoul National University Senate
2017-present
- FEBS Journal Editorial Board
2014-present
- Science Director/Member, Knowledge Awakening On Stage foundation (KAOS)
2014-2017
- Human Frontiers Science Fellowship, Postdoctoral Fellowship Review Board
2014.06-present
- Associate Dean, College of Natural Sciences, Seoul National University
2013.09-present
- Professor, School of Biological Sciences, College of Natural Sciences, Seoul National University
2011-2016
- Recipient Advisor, POSCO TJ Park Prize
2009-2017
- Grant Advisor, POSCO Science Fellowship
2008.08-2009.07
- Vice President, Basic Nursery School, Seoul National University
2004-2013.8
- Associate Professor, School of Biological Sciences, College of Natural Sciences, Seoul National University
2002-2003
- Research Assistant Professor, Molecular Biological Sciences, Ewha Womans University
2000-2002
- Wellcome Trust Fellow Harvard Medical School/Univ. of Washington, Seattle
1992-1995
- Senior Researcher, MokAm Life Sciences Research Center
Publications
Publications
- Choi E, Park P, Lee H, Lee Y, Kang G, Lee J, Han W, Lee H, Noh N, Lekomtsev S, Lee H. (2012) BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation. Developmental Cell, 22(2), 295-308
- Min J, Choi ES, Hwang K, Kim J, Sampath S, Venkitaraman AR, Lee H. (2012) BRCA2 is required for the maintenance of telomere homeostasis. J. Biol Chem. 287(7), 5091-5101
- Lee YK, Park, NH and Lee H (2012) Prognostic Value of Alternative Lengthening of Telomeres-Associated Biomarkers in Uterine Sarcoma and Uterine Carcinosarcoma. International Journal of Gynecological Cancer. 22(3), 434-441
- Jeong KH, Jeong JY, Lee HO, Choi E, Lee H (2010) Inhibition of Plk1 Induces Mitotic Infidelity and Embryonic Growth Defects in Developing Zebrafish Embryos. Dev. Biol. 345(1), 34-48
- Choi E, Choi H, Choi JY, Kim J, Lee H (2009) BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing in mitosis. EMBO J. 28: 2077-2089.
- Lee J, Sung K, Joo SY, Jeong J, Kim SK, Lee H (2022). Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis. Nature Communications. 13, 3396.
