바로가기 메뉴
본문 바로가기
푸터 바로가기
TOP

 

Faculty

SEONG, RHO HYUN Professor

Dept. Biological Sciences

Major Molecular Immunology
Lab Laboratory of Molecular Immunology
Contact+82-2-880-7567
E-mailrhseong@snu.ac.kr

Research

Immunology

Molecular Biology

1. T-cell Differentiation in the thymus
● Genetic and epigenetic control of T cell differentiation
● Control of thymocyte selection by transcription factors and chromatin remodeling complex

2. Differentiation of regulatory T-cells and Th17 cells in the periphery
● Control of regulatory T-cell development by transcription factors and chromatin remodeling complex
● Signaling factors regulating the differentiation and function of colonic Treg and Th17 cells

3. Regulation of early hematopoietic cell differentiation in the bone marrow
● Control of early B cell differentiation by chromatin remodeling complex and hematopoietic stromal cell factors
● Control of peripheral B cell differentiation by signaling factors

4. Genetic and epigenetic analysis of disease development
● Intestinal Bowel Diseases, Liver diseases using liver organoid culture

Education/Career

Education

2003.4-present

Professor

1997.2-2003.3

  • Associate Professor

1993.3-1997.2

  • Assistant Professor

1983.10-1990.1

  • Ph.D. : Stanford University, U.S.A.

1981.3-1983.2

  • Master

1977.3-1981.2

  •  Bachelor

Career

2007.1-Present

Secretary General, The World Society of Cell Biology Organizing Committee

2005.1-2005.12

General Affairs Operator, Korean Society for Molecular and Cellular Biology

2005-Present

RCFC Director, Research Center of Cell Function Control appointed by Ministry of Science and Technology / Science Foundation

2004.1-Present

Director, Korea Aid Association of National Vaccine Research Center

2003.3-2005.12

  • Bio-MAX Institute Project Operation Department Head, Seoul National University Bio-MAX Institute

2003. 4 – Present

  • Professor, School of Biological Sciences, Seoul National University

2002.5-2007.4

  •  International Research Advisor, International Vaccine Research Center

2001.1-2002.12 

  • Editor, Molecules and Cells (Journal of Korean Society for Molecular and Cellular Biology)

1999.1-2003.1

  • Director, Seoul National University SPF

1997.4-2003.3 

  • Associate Professor, Seoul National University Institute of Molecular Biology and Genetics

1996.12-Present

  • Board Chairman, Korean Zoology Association

1996.12-2000.11

  • Editor, Journal of Association of Korean Biological Sciences

995.12-Present

  • Board Chairman, Korean Immunology Association

1994.12-1996.11

  • Scientific Organizer, Korean Zoology Association

1993.3-1997.3

  • Assistant Professor, Seoul National University Institute of Molecular Biology and Genetics

Publications

Publications

  • S. Lee, J. Kim, H. Min, R.H. Seong. 2020. RORgt-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex. iScience 23, 101106
  • S. Hwang, C. Lee, K. Park, S. Oh, S. Jeon, B. Kang, Y. Kim, J. Oh, S.H. Jeon, Masanobu Satake, Ichiro Taniuchi, H. Lee & R.H. Seong. 2020. Twist2 promotes CD8+ T-cell differentiation by repressing ThPOK expression. Cell Death Diff https://doi.org/10.1038/s41418-020-0560-x
  • W. Kim, E. Kim, H. Min, M.G. Kim, Verena B. Eisenbeis, Amit K. Dutta, Igor Pavlovic, Henning J. Jessen, S. Kim, and R.H. Seong. 2019. Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton’s tyrosine kinase. Proc Natl Acad Sci U S A. 25;116(26):12952-12957.
  • Lee S, Park K, Kim J, Min H, Seong RH. 2018. Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.. EMBO Rep. 19(12):e45995
  • Kim, E., J. Beon, S. Lee, S.J. Park, H. Ahn, M.G. Kim, J.E. Park, W. Kim, J.-M. Yuk, S.-J Kang, S.-H Lee, E.-K. Jo, R.H. Seong*, S. Kim*. 2017. Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6″ for publication. Science Advances. 3(4) e1602296 DOI: 10.1126/sciadv.1602296. (*co-corresponding authors).
  • Choi, J., Y.-K. Kim, K. Park, D.-W. Kim, V.N. Kim and R.H. Seong. 2016. MicroRNA-139 controls proliferation and differentiation of myeloid progenitors and is associated with hematopoietic malignancy. Blood 128(17):2117-2129.
  • Oh, S., J. Oh, C. Lee, S.-J. Oh, S. Jeon, S.-S. Hwang, Y. Lee, and R.H. Seong. 2016. Expression of twist2 is controlled by T-cell receptor signaling and determines the survival and death during thymocyte selection. Cell Death Diff. 23(11) 1804-1814.
  • Jeon, S. and R.H. Seong. 2016. Anteroposterior limb skeletal patterning requires the bifurcating function of SWI/SNF chromatin remodeling complex in Hedgehog pathway. PLoS Genetics. 12(3): e1005915. doi:10.1371 /journal.pgen.1005915.
  • Choi, J., S. Jeon, S. Choi, K. Park, and R.H. Seong. 2015. The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression. Proc. Natl. Acad. Sci. 112(7):E718-27, 112(46):E6409.