Research
Immunology
Molecular Biology
1. T-cell Differentiation in the thymus
● Genetic and epigenetic control of T cell differentiation
● Control of thymocyte selection by transcription factors and chromatin remodeling complex
2. Differentiation of regulatory T-cells and Th17 cells in the periphery
● Control of regulatory T-cell development by transcription factors and chromatin remodeling complex
● Signaling factors regulating the differentiation and function of colonic Treg and Th17 cells
3. Regulation of early hematopoietic cell differentiation in the bone marrow
● Control of early B cell differentiation by chromatin remodeling complex and hematopoietic stromal cell factors
● Control of peripheral B cell differentiation by signaling factors
4. Genetic and epigenetic analysis of disease development
● Intestinal Bowel Diseases, Liver diseases using liver organoid culture
Education/Career
Education
2003.4-present
Professor
1997.2-2003.3
- Associate Professor
1993.3-1997.2
- Assistant Professor
1983.10-1990.1
- Ph.D. : Stanford University, U.S.A.
1981.3-1983.2
- Master
1977.3-1981.2
- Bachelor
Career
2007.1-Present
Secretary General, The World Society of Cell Biology Organizing Committee
2005.1-2005.12
General Affairs Operator, Korean Society for Molecular and Cellular Biology
2005-Present
RCFC Director, Research Center of Cell Function Control appointed by Ministry of Science and Technology / Science Foundation
2004.1-Present
Director, Korea Aid Association of National Vaccine Research Center
2003.3-2005.12
- Bio-MAX Institute Project Operation Department Head, Seoul National University Bio-MAX Institute
2003. 4 – Present
- Professor, School of Biological Sciences, Seoul National University
2002.5-2007.4
- International Research Advisor, International Vaccine Research Center
2001.1-2002.12
- Editor, Molecules and Cells (Journal of Korean Society for Molecular and Cellular Biology)
1999.1-2003.1
- Director, Seoul National University SPF
1997.4-2003.3
- Associate Professor, Seoul National University Institute of Molecular Biology and Genetics
1996.12-Present
- Board Chairman, Korean Zoology Association
1996.12-2000.11
- Editor, Journal of Association of Korean Biological Sciences
995.12-Present
- Board Chairman, Korean Immunology Association
1994.12-1996.11
- Scientific Organizer, Korean Zoology Association
1993.3-1997.3
- Assistant Professor, Seoul National University Institute of Molecular Biology and Genetics
Publications
Publications
- S. Lee, J. Kim, H. Min, R.H. Seong. 2020. RORgt-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex. iScience 23, 101106
- S. Hwang, C. Lee, K. Park, S. Oh, S. Jeon, B. Kang, Y. Kim, J. Oh, S.H. Jeon, Masanobu Satake, Ichiro Taniuchi, H. Lee & R.H. Seong. 2020. Twist2 promotes CD8+ T-cell differentiation by repressing ThPOK expression. Cell Death Diff https://doi.org/10.1038/s41418-020-0560-x
- W. Kim, E. Kim, H. Min, M.G. Kim, Verena B. Eisenbeis, Amit K. Dutta, Igor Pavlovic, Henning J. Jessen, S. Kim, and R.H. Seong. 2019. Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton’s tyrosine kinase. Proc Natl Acad Sci U S A. 25;116(26):12952-12957.
- Lee S, Park K, Kim J, Min H, Seong RH. 2018. Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.. EMBO Rep. 19(12):e45995
- Kim, E., J. Beon, S. Lee, S.J. Park, H. Ahn, M.G. Kim, J.E. Park, W. Kim, J.-M. Yuk, S.-J Kang, S.-H Lee, E.-K. Jo, R.H. Seong*, S. Kim*. 2017. Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6″ for publication. Science Advances. 3(4) e1602296 DOI: 10.1126/sciadv.1602296. (*co-corresponding authors).
- Choi, J., Y.-K. Kim, K. Park, D.-W. Kim, V.N. Kim and R.H. Seong. 2016. MicroRNA-139 controls proliferation and differentiation of myeloid progenitors and is associated with hematopoietic malignancy. Blood 128(17):2117-2129.
- Oh, S., J. Oh, C. Lee, S.-J. Oh, S. Jeon, S.-S. Hwang, Y. Lee, and R.H. Seong. 2016. Expression of twist2 is controlled by T-cell receptor signaling and determines the survival and death during thymocyte selection. Cell Death Diff. 23(11) 1804-1814.
- Jeon, S. and R.H. Seong. 2016. Anteroposterior limb skeletal patterning requires the bifurcating function of SWI/SNF chromatin remodeling complex in Hedgehog pathway. PLoS Genetics. 12(3): e1005915. doi:10.1371 /journal.pgen.1005915.
- Choi, J., S. Jeon, S. Choi, K. Park, and R.H. Seong. 2015. The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression. Proc. Natl. Acad. Sci. 112(7):E718-27, 112(46):E6409.
