바로가기 메뉴
본문 바로가기
푸터 바로가기
TOP

 

Faculty

ROH, SOUNG-HUN Associate Professor

Dept. Biological Sciences

Major Cryo-Electron Mcroscopy (Cryo-EM)
Lab Laboratory of Molecular Imaging
Contact+82-2-880-2135
E-mailshroh@snu.ac.kr

Research

Biochemistry

Biophysics 

Molecular Biology

Molecular machines and their assemblies range 10-100 nm in size and perform extremely complex but critical actions within the cell. Cryo-Electron microscopy (Cryo-EM) has now overcome many biophysical hurdles and finally become a major strategy in structural biology. Our research focus is driven by a diverse spectrum of challenging biological topics and to explore functional mechanism of molecular machines by achieving high resolution structures.

Education/Career

Education

2010.8-2015.4 

  • Ph.D. Baylor College of Medicine, USA, Biochemistry and Molecular Biology

2001.3-2003.2

  • M.S. Gwang-Ju Institute of Science and Technology (GIST), South Korea, Life Science.

1994.3-2001.2

  • B.S. Gyung-Book National University, South Korea, Microbiology

Career

2022- present

Associate Professor, School of Biological Sciences, Seoul National University

2018-2022

Assistant Professor, School of Biological Sciences, Seoul National University

2017-2018

Postdoctoral Research Fellow, Stanford University

2015-2017

 Postdoctoral Associate, Baylor College of Medicine

2004-2009

  •  LG life Science co. ltd
  •  

Publications

Publications

  • Walsh RW Jr*., Roh SH*, Gharpure A, Morales-Perez CL, Hibbs RE. “Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.” Nature 2018. doi:10.1038/s41586-018-0081-7. PMID:29720657
  • Roh SH, Stam NJ, Hryc CF, Couoh-Cardel S, Pintilie G, Chiu W, Wilkens S. “The 3.5-Å Cryo-EM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel.” Molecular Cell. 2018. S1097-2765(18)30104-7. PMID:29526695
  • Roh SH, Hryc CF, Jeong HH, Fei X, Jakana J, Lorimer GH, Chiu W. “Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM.” Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(31):8259-8264. PMID: 28710336
  • Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ. “Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.” Biophysical journal. 2016; 110(11):2377-2385. PMID: 27276256
  • Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ. “Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.” The Journal of biological chemistry. 2016; 291(9):4732-41. PMID: 26706127