Research
Cell Biology
Genetics
Molecular Biology
- Mechanism of Adipocyte Differentiation
- Gene Expression Regulation of Lipogenesis and Insulin-dependent Genes
- Molecular Mechanisms for Obesity and Diabetes
Education/Career
Education
1984 – 1988
- B.S. Dept. of Zoology, Seoul National University
1988 – 1990
- M.A. Cell & Molecular Biology, Seoul National University
1991 – 1996
- Ph.D. Dept. of Microbiology & Molecular Genetics, Harvard University, U.S.A
Career
1996 – 1997
Postdoctoral Fellow. Dana-Farber Cancer Inst., Harvard Medical School, U.S.A.
1997 – 2000
ostdoctoral Fellow. Cancer Research Center, Massachusetts Institute of Technology, U.S.A.
2000 – Present
Assistant Professor, Associate Professor, Professor, School of Biological Sciences, Seoul National University
2004 – Present
Associate Member of Korean Academy of Science and Technology
2005 – 2008
- Member of National Bioethics Evaluation, Ministry of Health & Welfare
2007 – 2008
- Visiting Professor, Dept. of Medicine, Univ. of California, San Diego, U.S.A.
2009 – 2011
- Director, Institute of Laboratory Animal Research, Seoul National University, Seoul, Korea
2011 – 2012
- Director, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
2011 – Present
- Director, Center for Adipose Tissue Remodeling, Creative Research Initiatives, Center for Studies on Structure-Function in Adipocyte
2013 – 2014
- Member of Presidential Advisory Council on Science & Technology
2014 – 2015
- Visiting Professor/ Project Scientist, Dept. of Pathology, Univ. of California, Los Angeles, U.S.A
2021 – Present
- Editor-in-Chief, Molecules and Cells
Publications
Publications
- Y. S. Lee, P. Li, J. Y. Huh, I. J. Hwang, M. Lu, J. I. Kim, M. Ham, S. Talukdar, A. Chen, W. Lu, G. Bandyopadhyay, R. Schwendener, J. Olefsky, and J. B. Kim*. Inflammation is necessary for long term but not short term HFD-induced insulin resistance. Diabetes, 60:2474-2483. 2011. 10
- I. Hwang, Y. J. Park, Y. R. Kim, Y. N. Kim, S Ka, H. Y. Lee, J. K. Seong, Y. J. Seok, and J. B. Kim*. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J., 29:2397-411, 2015. 06. (** This paper has been highlighted in Nat. Rev. Endo. 11:254 [2015])
- J. I. Kim, J. Y. Huh, J. H. Sohn, S. S. Choe, Y. S. Lee, C. Y. Lim, A Jo, S. B. Park, W. Han, and J. B. Kim*. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol. Cell. Biol., 35:1686-99, 2015.05 (** This paper is selected as a “Spotlight” paper. In the same issue (May 2015, Vol 35, Issue 10), Cover Figure has been selected with our data.)
- A. Y. Kim, Y. J. Park, X. Pan, K. C. Shin, S. H. Kwak, A. F. Bassas, R. M. Sallam, K. S. Park, A. A. Alfadda, A. Xu, and J. B. Kim*. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun., 6:7585, 2015. 07. (** This paper has been highlighted in Nat. Rev. Endo. 11:504 [2015])
- H. Jang, G. Y. Lee, C. P. Selby, G. Lee, Y. G. Jeon, J. H. Lee, K. K. Y. Cheng, P. Titchenell, M. J. Birnbaum, A. Xu, A. Sancar and J. B. Kim* . SREBP1c-CRY1 signaling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nat. Commun., 7:12180, 2016.07. (** This paper was invited from Cell Cycle journal for a Commentary Article.)
- J. Y. Huh, J. Park, J. I. Kim, Y. J. Park, Y. K. Lee and J. B. Kim*. Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity. Diabetes, 66:835-847, 2017.04. (** This paper was invited from Adipocyte Journal for a Commentary Review.)
- K. C. Shin, S. S. Choe, I. J. Hwang, J. Park, J. Yul, J. I. Kim, J. Ching, J.-P. Kovalik and J. B. Kim*. Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation. Nat Commun., 8:1087, 2017. 10.
- I. Hwang, K. Jo, K. C. Shin, J. I. Kim, Y. Ji, Y. J. Park, J. Park, Y. G. Jeon, S. Ka, S. Suk, H. L. Noh, S. S. Choe, A. Alfadda, J. K. Kim, S. Kim and J. B. Kim*. GABA stimulated adipose-derived stem cells suppress subcutaneous adipose tissue inflammation in obesity. Proc. Natl. Acad. Sci., 116:11936-11945, 2019. 06.
- J. Park, J. Y. Huh, J. Oh, J. I. Kim, S. M. Han, K. C. Shin, Y. G. Jeon, S. S. Choe, J. Park, and J. B. Kim*. Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity. Genes & Dev., 33:1657-1672, 2019. 10.
- J. Kong, Y. Ji, Y. G. Jeon, J. S. Han, K. H. Han, J. H. Lee, G. Lee, H. Jang, S. S. Choe, M. Baes and J. B. Kim*. Spatiotemporal contact between peroxisome and lipid droplet regulates fasting-induced lipolysis via PEX5. Nat Commun., DOI: 10.1038/s41467-019-14176-0, 2020. 01.
