Research
Cell Biology
Cell Biology
Immunology
Neurobiology
Our laboratory currently focuses on three major areas:
1) Stem cell interaction with its microenvironment during tissue regeneration and cancer
2) Development of 3-dimensional in vitro miniature organ systems for precise therapeutic intervention of various human diseases including human cancers and neurological disorders
To this end, we use various in vitro/in vivo approaches including mouse genetics and stem cell organoid culture.
Education/Career
Education
2001-2006
Ph.D., University of Michigan Medical School
1998-2000
- M.S., Korea University
1991-1998
- B.A., Korea University
Career
2022-current
Associate Professor, Seoul National University
2016-2022
Associate Professor, Pohang University of Science and Technology (POSTECH)
2014-2016
Assistant Professor, Oregon Health & Science University (OHSU) School of Medicine
2007-2014
Instructor, Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine
2006-2007
- Postdoctoral fellow, Harvard University
Publications
Publications
- Kim E, Choi S, Kang B, Kong J, Kim Y, Yoon WH, Lee HR, Kim S, Kim HM, Lee H, Yang C, Lee Y, Kang M, Roh TY, Jung S, Kim S, Ku J, Shin K. Creation of bladder assembloids mimicking tissue regeneration and cancer. Nature. 2020 Dec 16. doi: 10.1038/s41586-020-3034-x.
- Kong J, Lee H, Kim D, Han SK, Ha D, Shin K* , Kim S*. Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients. Nat Commun. 2020 Oct 30;11(1):5485 *Co-corresponding authors.
- Yoon WH, Lee HR, Kim S, Kim E, Ku J*, Shin K* , Jung S*. Use of inkjet-printed single cells to quantify intratumoralheterogeneity. Biofabrication. 2020 June 29; 12(3) Epub. *Co-corresponding authors.
- Kim S, Kim Y, Kong J, Kim E, Choi JH, Yuk HD, Lee H, Kim HR, Lee KH, Kang M, Roe JS, Moon KC, Kim S, Ku JH, Shin K. Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. eLIFE. 2019 Apr 30;8 Epub.
- Lim A^*, Shin K^* , Zhao C, Kawano S, Beachy PA*. Spatial organization of Hedgehog signaling regulates adult prostate branching via Hgf. Nat. Cell. Biol. 2014 Nov 2;Epub. *Co-corresponding authors.
- Shin K* , Lim A, Zhao C, Pan Y, Liao JC, Beachy PA*. Protective effect of stromal response to Hedgehog signaling in bladder cancer. Cancer Cell. 2014 Apr 20; Epub. *Co-corresponding authors.
- Shin K* , Lim A, Odegaard JI, Honeycutt JD, Kawano S, Hsieh MH, Beachy PA*. Cellular Origin of Bladder Neoplasia and Tissue Dynamics of its Progression to Invasive Carcinoma. Nat. Cell Biol. 2014 May;16(5):469-78. Highlighted in Nat. Rev. Cancer. 2014 Jun;14(6):386-7. *Co-corresponding authors. Highlighted in Nat. Rev. Urol. 2014 Jun;11(6):302.
- Shin K* , Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA*. Hedgehog/Wnt Feedback Supports Regenerative Proliferation of Bladder Stem Cell. Nature. 2011 Apr 7;472(7341):110-4. *Co-corresponding authors. Recommended by Faculty of 1000.
