SEOUL NATIONAL UNIVERSITY
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김재범 사진
  • 성명 김재범
  • 직위 교수
  • 학과 생명과학부
  • 전공 지방세포 및 에너지대사
  • 사무실 지방세포 및 에너지대사연구실
  • 홈페이지 https://biosci.snu.ac.kr/lamr
  • 이메일 jaebkim@snu.ac.kr
  • 연락처 02-880-4409
연구분야
분자생물학 세포생물학 유전학
1. Mechanism of Adipocyte Differentiation
2. Gene Expression Regulation of Lipogenesis and Insulin-dependent Genes
3. Molecular Mechanisms for Obesity and Diabetes
학력/경력
학력
  • - 1984 - 1988 서울대학교 자연대학 동물학과 학사
  • - 1988 - 1990 서울대학교 자연대학 동물학과 (분자생물학 전공) 석사
  • - 1991 - 1996 하버드대학교 분자유전학 박사
경력
  • - 1996 - 1997 하버드대학교 Dana-Farber Cancer Institute 박사후연구원
  • - 1997 - 2000 MIT Cancer Institute 박사후연구원
  • - 2000 - Present 서울대학교 생명과학부 조교수, 부교수, 정교수
  • - 2004 - Present 한국과학기술한림원 준회원, 정회원
  • - 2005 - 2008 보건복지부 국가생명윤리심의위원회 전문위원
  • - 2007 - 2008 Univ. of California, San Diego 초빙교수
  • - 2009 - 2011 서울대학교 실험동물자원관리원장
  • - 2010 - 2014 서울대학교 SPARC 부주임교수
  • - 2011 - 2012 서울대학교 유전공학연구소장
  • - 2011 - Present 지방조직 리모델링 창의연구단 단장, 지방세포 구조-기능 리더연구단장
  • - 2013 - 2014 국가과학기술자문위원회 자문위원
  • - 2014 - 2015 Univ. of California, Los Angeles 초빙교수
  • - 2021 - Present 한국분자세포생물학회지 (Molecules and Cells) 편집위원장 (Editor-in-Chief)
주요논문
  1. Y. S. Lee, P. Li, J. Y. Huh, I. J. Hwang, M. Lu, J. I. Kim, M. Ham, S. Talukdar, A. Chen, W. Lu, G. Bandyopadhyay, R. Schwendener, J. Olefsky, and J. B. Kim*. Inflammation is necessary for long term but not short term HFD-induced insulin resistance. Diabetes, 60:2474-2483. 2011. 10
  2. I. Hwang, Y. J. Park, Y. R. Kim, Y. N. Kim, S Ka, H. Y. Lee, J. K. Seong, Y. J. Seok, and J. B. Kim*. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J., 29:2397-411, 2015. 06. (** This paper has been highlighted in Nat. Rev. Endo. 11:254 [2015])
  3. J. I. Kim, J. Y. Huh, J. H. Sohn, S. S. Choe, Y. S. Lee, C. Y. Lim, A Jo, S. B. Park, W. Han, and J. B. Kim*. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol. Cell. Biol., 35:1686-99, 2015.05 (** This paper is selected as a “Spotlight” paper. In the same issue (May 2015, Vol 35, Issue 10), Cover Figure has been selected with our data.)
  4. A. Y. Kim, Y. J. Park, X. Pan, K. C. Shin, S. H. Kwak, A. F. Bassas, R. M. Sallam, K. S. Park, A. A. Alfadda, A. Xu, and J. B. Kim*. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun., 6:7585, 2015. 07. (** This paper has been highlighted in Nat. Rev. Endo. 11:504 [2015])
  5. H. Jang, G. Y. Lee, C. P. Selby, G. Lee, Y. G. Jeon, J. H. Lee, K. K. Y. Cheng, P. Titchenell, M. J. Birnbaum, A. Xu, A. Sancar and J. B. Kim* . SREBP1c-CRY1 signaling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nat. Commun., 7:12180, 2016.07. (** This paper was invited from Cell Cycle journal for a Commentary Article.)
  6. J. Y. Huh, J. Park, J. I. Kim, Y. J. Park, Y. K. Lee and J. B. Kim*. Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity. Diabetes, 66:835-847, 2017.04. (** This paper was invited from Adipocyte Journal for a Commentary Review.)
  7. K. C. Shin, S. S. Choe, I. J. Hwang, J. Park, J. Yul, J. I. Kim, J. Ching, J.-P. Kovalik and J. B. Kim*. Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation. Nat Commun., 8:1087, 2017. 10.
  8. I. Hwang, K. Jo, K. C. Shin, J. I. Kim, Y. Ji, Y. J. Park, J. Park, Y. G. Jeon, S. Ka, S. Suk, H. L. Noh, S. S. Choe, A. Alfadda, J. K. Kim, S. Kim and J. B. Kim*. GABA stimulated adipose-derived stem cells suppress subcutaneous adipose tissue inflammation in obesity. Proc. Natl. Acad. Sci., 116:11936-11945, 2019. 06.
  9. J. Park, J. Y. Huh, J. Oh, J. I. Kim, S. M. Han, K. C. Shin, Y. G. Jeon, S. S. Choe, J. Park, and J. B. Kim*. Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity. Genes & Dev., 33:1657-1672, 2019. 10.
  10. J. Kong, Y. Ji, Y. G. Jeon, J. S. Han, K. H. Han, J. H. Lee, G. Lee, H. Jang, S. S. Choe, M. Baes and J. B. Kim*. Spatiotemporal contact between peroxisome and lipid droplet regulates fasting-induced lipolysis via PEX5. Nat Commun., DOI: 10.1038/s41467-019-14176-0, 2020. 01.

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