연구분야
면역학
발달 및 발생생물학
생물물리학
신경생물학
아래의 3가지 분야에 관심을 가지고 연구를 진행하고 있습니다.
2) 다양한 유전적 변이를 포함하는 암질환, 조현병이나 자폐증과 같은 뇌질환을 비롯한 다양한 인간 질병 치료법 개발을 위한 3차원 체외 미니 조직/장기 모델 시스템 개발
3) 생체 내 조직 프로그래밍 및 유전체 편집 기반의 재생 의학 연구
Our laboratory currently focuses on three major areas:
1) Stem cell interaction with its microenvironment during tissue regeneration and cancer
2) Development of 3-dimensional in vitro miniature organ systems for precise therapeutic intervention of various human diseases including human cancers and neurological disorders
To this end, we use various in vitro/in vivo approaches including mouse genetics and stem cell organoid culture.
학력/경력
학력
2001-2006
Ph.D., University of Michigan Medical School
1998-2000
- M.S., Korea University
1991-1998
- B.A., Korea University
경력
2022-current
Associate Professor, Seoul National University
2016-2022
Associate Professor, Pohang University of Science and Technology (POSTECH)
2014-2016
Assistant Professor, Oregon Health & Science University (OHSU) School of Medicine
2007-2014
Instructor, Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine
2006-2007
- Postdoctoral fellow, Harvard University
주요논문
주요논문
- Kim E, Choi S, Kang B, Kong J, Kim Y, Yoon WH, Lee HR, Kim S, Kim HM, Lee H, Yang C, Lee Y, Kang M, Roh TY, Jung S, Kim S, Ku J, Shin K. Creation of bladder assembloids mimicking tissue regeneration and cancer. Nature. 2020 Dec 16. doi: 10.1038/s41586-020-3034-x.
- Kong J, Lee H, Kim D, Han SK, Ha D, Shin K* , Kim S*. Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients. Nat Commun. 2020 Oct 30;11(1):5485 *Co-corresponding authors.
- Yoon WH, Lee HR, Kim S, Kim E, Ku J*, Shin K* , Jung S*. Use of inkjet-printed single cells to quantify intratumoralheterogeneity. Biofabrication. 2020 June 29; 12(3) Epub. *Co-corresponding authors.
- Kim S, Kim Y, Kong J, Kim E, Choi JH, Yuk HD, Lee H, Kim HR, Lee KH, Kang M, Roe JS, Moon KC, Kim S, Ku JH, Shin K. Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. eLIFE. 2019 Apr 30;8 Epub.
- Lim A^*, Shin K^* , Zhao C, Kawano S, Beachy PA*. Spatial organization of Hedgehog signaling regulates adult prostate branching via Hgf. Nat. Cell. Biol. 2014 Nov 2;Epub. *Co-corresponding authors.
- Shin K* , Lim A, Zhao C, Pan Y, Liao JC, Beachy PA*. Protective effect of stromal response to Hedgehog signaling in bladder cancer. Cancer Cell. 2014 Apr 20; Epub. *Co-corresponding authors.
- Shin K* , Lim A, Odegaard JI, Honeycutt JD, Kawano S, Hsieh MH, Beachy PA*. Cellular Origin of Bladder Neoplasia and Tissue Dynamics of its Progression to Invasive Carcinoma. Nat. Cell Biol. 2014 May;16(5):469-78. Highlighted in Nat. Rev. Cancer. 2014 Jun;14(6):386-7. *Co-corresponding authors. Highlighted in Nat. Rev. Urol. 2014 Jun;11(6):302.
- Shin K* , Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA*. Hedgehog/Wnt Feedback Supports Regenerative Proliferation of Bladder Stem Cell. Nature. 2011 Apr 7;472(7341):110-4. *Co-corresponding authors. Recommended by Faculty of 1000.
Contacts
Mailing Address
Shin lab
Seoul National University Department of Biological Sciences
The Institute of Molecular Biology & Genetics, Rm306
1 Gwanak-ro, Gwanak-gu, Seoul 08826
South Korea
Phone
Office: 82-2-880-8224
Lab: 82-2-880-8225
(@shin_lab_)